Substantia nigra is effexor xr no prescription located in the brain stem involved in the regulation of acts of chewing, swallowing and their sequences as well as in the coordination of small and precise movements of the fingers, for example, writing, playing the violin, the piano. Neurons of this nucleus is synthesized dopamine supplied to the basal nuclei of the brain. The latter plays an important role in the control of complex motor acts. The defeat of the substantia nigra leads to the degeneration of dopaminergic fibers projecting to the striatum, disruption of fine movements of the fingers, the development of muscle rigidity and tremors (Parkinson's disease).    

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